From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme

Swenson, SA; Moore, CM; Marcero, JR; Medlock, AE; Reddi, AR; Khalimonchuk, O

Khalimonchuk, O (corresponding author), Univ Nebraska, Dept Biochem, Lincoln, NE 68588 USA.; Reddi, AR (corresponding author), Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA.; Medlock, AE (corresponding author), Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA.; Medlock, AE (corresponding author), Augusta Univ Univ Georgia Med Partnership, Athens, GA 30602 USA.; Reddi, AR (corresponding author), Georgia Inst Technol, Parker Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA.; Khalimonchuk, O (corresponding author), Univ Nebraska, Nebraska Redox Biol Ctr, Lincoln, NE 68588 USA.; Khalimonchuk, O (corresponding author), Fred & Pamela Buffett Canc Ctr, Omaha, NE 68105 USA.

CELLS, 2020; 9 (3):

Abstract

Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for virtually all aerobic life. Heme synthesis is initiated and c......

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