Intratumoral Delivery of Plasmid IL12 Via Electroporation Leads to Regression of Injected and Noninjected Tumors in Merkel Cell Carcinoma

Bhatia, S; Longino, NV; Miller, NJ; Kulikauskas, R; Iyer, JG; Ibrani, D; Blom, A; Byrd, DR; Parvathaneni, U; Twitty, CG; Campbell, JS; Le, MH; Gargosky, S; Pierce, RH; Heller, R; Daud, AI; Nghiem, P

CLINICAL CANCER RESEARCH, 2020; 26 (3): 598

Abstract

Purpose: IL12 promotes adaptive type I immunity and has demonstrated antitumor efficacy, but systemic administration leads to severe adverse events (A......

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