Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones

Elzahhar, PA; Alaaeddine, R; Ibrahim, TM; Nassra, R; Ismail, A; Chua, BSK; Frkic, RL; Bruning, JB; Wallner, N; Knape, T; von Knethen, A; Labib, H; El-Yazbi, AF; Belal, ASF

Belal, ASF (reprint author), Alexandria Univ, Fac Pharm, Dept Pharmaceut Chem, Alexandria 21521, Egypt.; El-Yazbi, AF (reprint author), Amer Univ Beirut, Fac Med, Dept Pharmacol & Toxicol, Beirut, Lebanon.; El-Yazbi, AF (reprint author), Amer Univ Beirut,

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019; 167 (): 562

Abstract

In search for effective multi-targeting drug ligands (MTDLs) to address low-grade inflammatory changes of metabolic disorders, we rationally designed ......

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