Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide

Sishc, BJ; Ding, LH; Nam, TK; Heer, CD; Rodman, SN; Schoenfeld, JD; Fath, MA; Saha, D; Pulliam, CF; Langen, B; Beardsley, RA; Riley, DP; Keene, JL; Spitz, DR; Story, MD

Story, MD (corresponding author), Univ Texas Southwestern Med Ctr Dallas, Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA.; Spitz, DR (corresponding author), Galera Therapeut Inc, 2 West Liberty Blvd,Suite 110, Malvern, PA 19355 USA.

SCIENCE TRANSLATIONAL MEDICINE, 2021; 13 (593):

Abstract

Avasopasem manganese (AVA or GC4419), a selective superoxide dismutase mimetic, is in a phase 3 clinical trial (NCT03689712) as a mitigator of radiati......

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