General Synthesis of 3-Azabicyclo[3.1.1]heptanes and Evaluation of Their Properties as Saturated Isosteres

Dibchak, D; Snisarenko, M; Mishuk, A; Shablykin, O; Bortnichuk, L; Klymenko-Ulianov, O; Kheylik, Y; Sadkova, IV; Rzepa, HS; Mykhailiuk, PK

Mykhailiuk, PK (通讯作者)，Enamine Ltd, Chervonotkatska 60, UA-02094 Kiev, Ukraine.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023; 62 (39):

Abstract

A general approach to 3-azabicyclo[3.1.1]heptanes by reduction of spirocyclic oxetanyl nitriles was developed. The mechanism, scope, and scalability o......

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