Ripretinib and MEK Inhibitors Synergize to Induce Apoptosis in Preclinical Models of GIST and Systemic Mastocytosis

Gupta, A; Singh, J; Garcia-Valverde, A; Serrano, C; Flynn, DL; Smith, BD

Smith, BD (corresponding author), Deciphera Pharmaceut LLC, 200 Smith St, Waltham, MA 02451 USA.

MOLECULAR CANCER THERAPEUTICS, 2021; 20 (7): 1234

Abstract

The majority of gastrointestinal stromal tumors (GIST) harbor constitutively activating mutations in KIT tyrosine kinase. Imatinib, sunitinib, and reg......

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