Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition

Wood, DJ; Korolchuk, S; Tatum, NJ; Wang, LZ; Endicott, JA; Noble, MEM; Martin, MP

Noble, MEM; Martin, MP (reprint author), Newcastle Univ, Sch Med, Northern Inst Canc Res, Newcastle Canc Ctr, Paul OGorman Bldg,Framlington Pl, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.

CELL CHEMICAL BIOLOGY, 2019; 26 (1): 121

Abstract

Dysregulation of the cell cycle characterizes many cancer subtypes, providing a rationale for developing cyclin-dependent kinase (CDK) inhibitors. Pot......

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