Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines

Cao, P; Chen, CM; Liu, A; Shan, QH; Zhu, X; Jia, CH; Peng, XQ; Zhang, MJ; Farzinpour, Z; Zhou, WJ; Wang, HT; Zhou, JN; Song, XY; Wang, LC; Tao, WJ; Zheng, CJ; Zhang, Y; Ding, YQ; Jin, Y; Xu, L; Zhang, Z

Jin, Y; Zhang, Z (corresponding author), Univ Sci & Technol China, Affiliated Hosp 1, Dept Anesthesiol, Div Life Sci & Med,USTC,Hefei Natl Lab Phys Sci &, Hefei 230036, Peoples R China.; Xu, L (corresponding author), Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China.; Xu, L (corresponding author), Chinese Acad Sci, Kunming Inst Zool, Lab Learning & Memory, Kunming 650223, Yunnan, Peoples R China.

NEURON, 2021; 109 (16): 2573

Abstract

Early-life inflammation increases the risk for depression in later life. Here, we demonstrate how early-life inflammation causes adolescent depressive......

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