Destabilization of microrchidia family CW-type zinc finger 2 via the cyclin-dependent kinase 1-chaperone-mediated autophagy pathway promotes mitotic arrest and enhances cancer cellular sensitivity to microtubule-targeting agents

Hu, SY; Qian, JX; Yang, SY; Andriani, L; Liao, L; Deng, L; Huang, MY; Zhang, YL; Zhang, FL; Shao, ZM; Li, DQ

Zhang, FL (通讯作者)，Fudan Univ, Canc Inst, Shanghai Med Coll, Shanghai Canc Ctr, Shanghai 200032, Peoples R China.;Shao, ZM; Li, DQ (通讯作者)，Fudan Univ, Dept Breast Surg, Shanghai 200032, Peoples R China.;Shao, ZM; Li, DQ (通讯作者)，Fudan Univ, Canc Inst, Shanghai Med Coll, Shanghai Canc Ctr, Shanghai 200032, Peoples R China.

CLINICAL AND TRANSLATIONAL MEDICINE, 2023; 13 (3):

Abstract

BackgroundMicrotubule-targeing agents (MTAs), such as paclitaxel (PTX) and vincristine (VCR), kill cancer cells through activtion of the spindle assem......

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