Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515

Papeo, G; Orsini, P; Avanzi, NR; Borghi, D; Casale, E; Ciomei, M; Cirla, A; Desperati, V; Donati, D; Felder, ER; Galvani, A; Guanci, M; Isacchi, A; Posteri, H; Rainoldi, S; Riccardi-Sirtor, F; Scolaro, A; Montagnoli, A

Papeo, G (reprint author), Nerviano Med Sci Srl, Oncol, Viale Pasteur 10, I-20014 Milan, Italy.

ACS MEDICINAL CHEMISTRY LETTERS, 2019; 10 (4): 534

Abstract

Poly(ADP-ribose) polymerase-1 (PARP-1) is an enzyme involved in signaling and repair of DNA single strand breaks. PARP-1 employs NAD+ to modify substr......

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