Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines

Krasavin, M; Adamchik, M; Bubyrev, A; Heim, C; Maiwald, S; Zhukovsky, D; Zhmurov, P; Bunev, A; Hartmann, MD

Krasavin, M (通讯作者)，St Petersburg State Univ, St Petersburg 199034, Russia.;Hartmann, MD (通讯作者)，Max Planck Inst Biol, Dept Prot Evolut, Tubingen, Germany.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023; 246 ():

Abstract

To expand the chemical toolkit for targeted protein degradation, we report the generation of a new series of non -thalidomide Cereblon (CRBN) ligands.......

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