Neuregulin signaling mediates the acute and sustained antidepressant effects of subanesthetic ketamine

Grieco, SF; Qiao, X; Johnston, KG; Chen, LJ; Nelson, RR; Lai, C; Holmes, TC; Xu, XM

Xu, XM (corresponding author), Univ Calif Irvine, Sch Med, Dept Anat & Neurobiol, Irvine, CA 92697 USA.; Xu, XM (corresponding author), Univ Calif Irvine, Ctr Neural Circuit Mapping, Irvine, CA 92697 USA.; Xu, XM (corresponding author), Univ Calif Irvine, Dept Biomed Engn, Irvine, CA 92697 USA.; Xu, XM (corresponding author), Univ Calif Irvine, Dept Microbiol & Mol Genet, Irvine, CA 92697 USA.

TRANSLATIONAL PSYCHIATRY, 2021; 11 (1):

Abstract

Subanesthetic ketamine evokes rapid antidepressant effects in human patients that persist long past ketamine's chemical half-life of similar to 2 h. K......

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