Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of K(Ca)2 Channels

El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M

Parang, K; Zhang, M (通讯作者),Chapman Univ, Dept Biomed & Pharmaceut Sci, Sch Pharm, Irvine, CA 92618 USA.;Bezprozvanny, I (通讯作者),Univ Texas Southwestern Med Ctr Dallas, Dept Physiol, Dallas, TX 75390 USA.

JOURNAL OF MEDICINAL CHEMISTRY, 2022; 65 (1): 303

Abstract

A series of modified N-cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine (CyPPA) analogues were synthesized by replacing the cyclo......

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