ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage

Perkhofer, L; Schmitt, A; Carrasco, MCR; Ihle, M; Hampp, S; Ruess, DA; Hessmann, E; Russell, R; Lechel, AE; Azoitei, N; Lin, Q; Liebau, S; Hohwieler, M; Bohnenberger, H; Lesina, M; Algul, H; Gieldon, L; Schrock, E; Gaedcke, J; Wagner, M; Wiesmuller,

Frappart, PO; Kleger, A (reprint author), Univ Hosp Ulm, Dept Internal Med 1, Albert Einstein Allee 23, D-89081 Ulm, Germany.

CANCER RESEARCH, 2017; 77 (20): 5576

Abstract

Pancreatic ductal adenocarcinomas (PDAC) harbor recurrent functional mutations of the master DNA damage response kinase ATM, which has been shown to a......

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