MCC950 directly targets the NLRP3 ATP- hydrolysis motif for inflammasome inhibition

Coll, RC; Hill, JR; Day, CJ; Zamoshnikova, A; Boucher, D; Massey, NL; Chitty, JL; Fraser, JA; Jennings, MP; Robertson, AAB; Schroder, K

Coll, RC; Robertson, AAB; Schroder, K (reprint author), Univ Queensland, Inst Mol Biosci, St Lucia, Qld, Australia.; Coll, RC; Robertson, AAB; Schroder, K (reprint author), Univ Queensland, IMB Ctr Inflammat & Dis Res, St Lucia, Qld, Australia.; Schroder,

NATURE CHEMICAL BIOLOGY, 2019; 15 (6): 556

Abstract

Inhibition of the NLRP3 inflammasome is a promising strategy for the development of new treatments for inflammatory diseases. MCC950 is a potent and s......

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