Population-wide gene disruption in the murine lung epithelium via AAV-mediated delivery of CRISPR-Cas9 components

Chen, HL; Durinck, S; Patel, H; Foreman, O; Mesh, K; Eastham, J; Caothien, R; Newman, RJ; Roose-Girma, M; Darmanis, S; Warming, S; Lattanzi, A; Liang, YX; Haley, B

Liang, YX (通讯作者)，Genentech Inc, Dept Microchem Prote Lip Id & Next Generat Sequenc, DNA Way, South San Francisco, CA 94080 USA.;Haley, B (通讯作者)，Genentech Inc, Dept Mol Biol, DNA Way, South San Francisco, CA 94080 USA.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2022; 27 (): 431

Abstract

With the aim of expediting drug target discovery and validation for respiratory diseases, we developed an optimized method for in situ somatic gene di......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索