TDP-43 controls lysosomal pathways thereby determining its own clearance and cytotoxicity

Leibiger, C; Deisel, J; Aufschnaiter, A; Ambros, S; Tereshchenko, M; Verheijen, BM; Buttner, S; Braun, RJ

Braun, RJ (reprint author), Univ Bayreuth, Inst Cell Biol, Univ Str 30, D-95447 Bayreuth, Germany.

HUMAN MOLECULAR GENETICS, 2018; 27 (9): 1593

Abstract

TDP-43 is a nuclear RNA-binding protein whose cytoplasmic accumulation is the pathological hallmark of amyotrophic lateral sclerosis (ALS). For a bett......

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