TGF beta 2 and TGF beta 3 isoforms drive fibrotic disease pathogenesis

Sun, TH; Huang, ZY; Liang, WC; Yin, JP; Lin, WY; Wu, J; Vernes, JM; Lutman, J; Caplazi, P; Jeet, S; Wong, T; Wong, MD; DePianto, DJ; Morshead, KB; Sun, KH; Modrusan, Z; Vander Heiden, JA; Abbas, AR; Zhang, H; Xu, M; N'diaye, EN; Roose-Girma, M; Wolters, PJ; Yadav, R; Sukumaran, S; Ghilardi, N; Corpuz, R; Emson, C; Meng, YG; Ramalingam, TR; Lupardus, P; Brightbill, HD; Seshasayee, D; Wu, Y; Arron, JR

Sun, TH; Arron, JR (corresponding author), Genentech Inc, Dept Immunol Discovery, 1 DNA Way, San Francisco, CA 94080 USA.

SCIENCE TRANSLATIONAL MEDICINE, 2021; 13 (605):

Abstract

Transforming growth factor-beta (TGF beta) is a key driver of fibrogenesis. Three TGF beta isoforms (TGF beta 1, TGF beta 2, and TGF beta 3) in mammal......

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