PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor

Xu, H; Jesson, MI; Seneyiratne, UI; Lin, TH; Shari, MN; Xue, L; Nguyen, C; Everley, RA; Trujillo, JI; Johnson, DS; Point, GR; Thorarensen, A; Kilty, L; Telliez, JB

Telliez, JB (reprint author), Pfizer Worldwide R&D, Inflammat & Immunol, 610 Main St, Cambridge, MA 02139 USA.

ACS CHEMICAL BIOLOGY, 2019; 14 (6): 1235

Abstract

PF-06651600 was developed as an irreversible inhibitor of JAK3 with selectivity over the other three JAK isoforms. A high level of selectivity toward ......

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