Design, synthesis and evaluation of the Brigatinib analogues as potent inhibitors against tertiary EGFR mutants (EGFR(del19/T790M/C797S) and EGFR(L858R/T790M/C797S))

Fang, HT; Wu, YM; Xiao, QT; He, DB; Zhou, TR; Liu, WZ; Yang, CH; Xie, YL

Xie, YL (通讯作者)，Wigen Biomed Technol Shanghai Co Ltd, 11Lane 67,Libing Rd, Shanghai 201210, Peoples R China.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2022; 72 ():

Abstract

Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have demonstrated encouraging clinical outcomes for patients with EGF......

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