An etanercept O-glycovariant with enhanced potency

Biel, TG; Faison, T; Matthews, AM; Zou, GZ; Ortega-Rodriguez, U; Pegues, MA; Azer, N; Gomez, F; Johnson, S; Rogstad, S; Chen, K; Xie, H; Agarabi, C; Rao, VA; Ju, TZ

Ju, TZ (通讯作者),US FDA, Off Biotechnol Prod, Ctr Drug Evaluat & Res, 10903 New Hampshire Ave,Bldg 52 Bldg 2120, Silver Spring, MD 20993 USA.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2022; 25 (): 124

Abstract

Most therapeutic proteins are glycosylated with N-glycans and/or O-glycans. N-glycans on therapeutic proteins have been extensively studied for their ......

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