Cinacalcet corrects biased allosteric modulation of CaSR by AHH autoantibody

Makita, N; Ando, T; Sato, J; Manaka, K; Mitani, K; Kikuchi, Y; Niwa, T; Ootaki, M; Takeba, Y; Matsumoto, N; Kawakami, A; Ogawa, T; Nangaku, M; Iiri, T

Makita, N (reprint author), 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138655, Japan.; Iiri, T (reprint author), 2-16-1 Sugao,Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan.

JCI INSIGHT, 2019; 4 (8):

Abstract

Biased agonism is a paradigm that may explain the selective activation of a signaling pathway via a GPCR that activates multiple signals. The autoanti......

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