A New Family of Jumonji C Domain-Containing KDM Inhibitors Inspired by Natural Product Purpurogallin

Souto, JA; Sarno, F; Nebbioso, A; Papulino, C; Alvarez, R; Lombino, J; Perricone, U; Padova, A; Altucci, L; de Lera, AR

de Lera, AR (corresponding author), Univ Vigo, Fac Quim, Dept Quim Organ, Vigo, Spain.; de Lera, AR (corresponding author), Univ Vigo, Ctr Invest Biomed CINBIO, Vigo, Spain.; Altucci, L (corresponding author), Univ Delia Campania L Vanvitelli, Dipartimento Med Precis, Naples, Italy.

FRONTIERS IN CHEMISTRY, 2020; 8 ():

Abstract

Aberrant epigenetic modifications are involved in cancer development. Jumonji C domain-containing histone lysine demethylases (KDMs) are found mainly ......

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