Loss of ARID1A activates mTOR signaling and SOX9 in gastric adenocarcinoma-rationale for targeting ARID1A deficiency

Dong, XC; Song, SM; Li, Y; Fan, YB; Wang, LL; Wang, RP; Huo, LF; Scott, A; Xu, Y; Pizzi, MP; Ma, L; Wang, Y; Jin, JK; Zhao, W; Yao, XD; Johnson, RL; Wang, LH; Wang, ZN; Peng, G; Ajani, JA

Song, SM; Ajani, JA (通讯作者),Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Unit 426,1515 Holcombe Blvd, Houston, TX 77030 USA.

GUT, 2022; 71 (3): 467

Abstract

Background Gastric adenocarcinoma (GAC) is a lethal disease with limited therapeutic options. Genetic alterations in chromatin remodelling gene AT-ric......

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