Constitutive internalization across therapeutically targeted GPCRs correlates with constitutive activity

Schmidt, JH; Perslev, M; Bukowski, L; Stoklund, M; Herborg, F; Herlo, R; Madsen, KL

Herlo, R; Madsen, KL (corresponding author), Univ Copenhagen, Mol Neuropharmacol & Genet Lab, Lundbeck Fdn Ctr Biomembranes Nanomed, Panum Inst,Fac Hlth & Med Sci,Dept Neurosci, Maersk Tower, DK-2200 Copenhagen N, Denmark.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2020; 126 (): 116

Abstract

While the physiological function and mechanisms of agonist-dependent G protein-coupled receptor (GPCR) internalization have been extensively studied, ......

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