Optimization of WZ4003 as NUAK inhibitors against human colorectal cancer

Yang, HL; Wang, XB; Wang, C; Yin, FC; Qu, LL; Shi, CJ; Zhao, JH; Li, S; Ji, LM; Peng, W; Luo, H; Cheng, MS; Kong, LY

Kong, LY (corresponding author), China Pharmaceut Univ, Dept Nat Med Chem, Jiangsu Key Lab Bioact Nat Prod Res, Nanjing 210009, Peoples R China.; Kong, LY (corresponding author), China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, Nanjing 210009, Peoples R China.; Cheng, MS (corresponding author), Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 210 ():

Abstract

NUAK, the member of AMPK (AMP-activated protein kinase) family of protein kinases, is phosphorylated and activated by the LKB1 (liver kinase B1) tumor......

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