Structure-based discovery of receptor tyrosine kinase AXL degraders with excellent anti-tumor activity by selectively degrading AXL and inducing methuosis

Shi, W; Feng, ZY; Chi, FL; Zhou, JQ; Qiu, QQ; Jiang, YX; Chen, S; Zhong, Y; Jia, HT; Huang, WL; Qian, H

Qian, H (通讯作者)，China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, 24 Tongjiaxiang, Nanjing 210009, Peoples R China.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022; 234 ():

Abstract

The receptor tyrosine kinase (RTK) anexelekto (AXL) is mutated and/or overexpressed in various malignancies, and plays a central role in tumor develop......

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