Constructing ion channels from water-soluble alpha-helical barrels

Scott, AJ; Niitsu, A; Kratochvil, HT; Lang, EJM; Sengel, JT; Dawson, WM; Mahendran, KR; Mravic, M; Thomson, AR; Brady, RL; Liu, LJ; Mulholland, AJ; Bayley, H; DeGrado, WF; Wallace, MI; Woolfson, DN

Woolfson, DN (corresponding author), Univ Bristol, Sch Chem, Bristol, Avon, England.; Woolfson, DN (corresponding author), Univ Bristol, Sch Biochem, Bristol, Avon, England.; Woolfson, DN (corresponding author), Univ Bristol, Bristol BioDesign Inst, Bristol, Avon, England.

NATURE CHEMISTRY, 2021; 13 (7): 643

Abstract

The design of peptides that assemble in membranes to form functional ion channels is challenging. Specifically, hydrophobic interactions must be desig......

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