Generation of a live attenuated influenza A vaccine by proteolysis targeting

Si, LL; Shen, Q; Li, J; Chen, L; Shen, JY; Xiao, X; Bai, HQ; Feng, T; Ye, AY; Li, L; Zhang, CH; Li, Z; Wang, P; Oh, CY; Nurani, A; Niu, SW; Zhang, CX; Wei, XQ; Yuan, WQ; Liao, H; Huang, XJ; Wang, N; Tian, WX; Tian, HW; Li, L; Liu, XH; Plebani, R

Si, LL (通讯作者)，Chinese Acad Sci, Shenzhen Inst Synthet Biol, Shenzhen Inst Adv Technol, CAS Key Lab Quantitat Engn Biol, Shenzhen, Peoples R China.

NATURE BIOTECHNOLOGY, 2022; 40 (9): 1370

Abstract

The usefulness of live attenuated virus vaccines has been limited by suboptimal immunogenicity, safety concerns or cumbersome manufacturing processes ......

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