Fasiglifam (TAK-875) Alters Bile Acid Homeostasis in Rats and Dogs: A Potential Cause of Drug Induced Liver Injury

Wolenski, FS; Zhu, AZX; Johnson, M; Yu, SX; Moriya, Y; Ebihara, T; Csizmadia, V; Grieves, J; Paton, M; Liao, MX; Gemski, C; Pan, LP; Vakilynejad, M; Dragan, YP; Chowdhury, SK; Kirby, PJ

Wolenski, FS (reprint author), Takeda Pharmaceut Int Co, Cambridge, MA 02139 USA.

TOXICOLOGICAL SCIENCES, 2017; 157 (1): 50

Abstract

Fasiglifam (TAK-875), a Free Fatty Acid Receptor 1 (FFAR1) agonist in development for the treatment of type 2 diabetes, was voluntarily terminated in ......

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