NMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency In Vivo

Di Stefano, M; Loreto, A; Orsomando, G; Mori, V; Zamporlini, F; Hulse, RP; Webster, J; Donaldson, LF; Gering, M; Raffaelli, N; Coleman, MP; Gilley, J; Conforti, L

Conforti, L (reprint author), Univ Nottingham, Sch Med, Sch Life Sci, Nottingham NG7 2UH, England.; Gilley, J (reprint author), Univ Cambridge, Dept Clin Neurosci, John Van Geest Ctr Brain Repair, Forvie Site,Robinson Way, Cambridge CB2 0PY, England.; Gil

CURRENT BIOLOGY, 2017; 27 (6): 784

Abstract

Axons require the axonal NAD-synthesizing enzyme NMNAT2 to survive. Injury or genetically induced depletion of NMNAT2 triggers axonal degeneration or ......

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