Metabolic Activation of Perampanel Mediated by CYP1A2

Ding, ZF; Wang, X; Zhang, N; Sun, C; Zhao, GD; Peng, Y; Zheng, J

Peng, Y; Zheng, J (通讯作者)，Shenyang Pharmaceut Univ, Wuya Coll Innovat, Shenyang 110016, Liaoning, Peoples R China.;Zheng, J (通讯作者)，Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Key Lab Pharmaceut Guizhou Prov, Guiyang 550025, Guizhou, Peoples R China.;Zheng, J (通讯作者)，Guizhou Med Univ, Key Lab Environm Pollut Monitoring & Dis Control, Minist Educ, Guiyang 550025, Peoples R China.

CHEMICAL RESEARCH IN TOXICOLOGY, 2022; 35 (3): 490

Abstract

Perampanel (PRP), a noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid (AMPA) receptor antagonist with high selectivity, has been......

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