OSU-A9 induced-reactive oxygen species cause cytotoxicity in duodenal and gastric cancer cells by decreasing phosphorylated nuclear pyruvate kinase M2 protein levels

Chiu, CF; Weng, JR; Lee, SL; Wu, CY; Chu, PC; Shan, YS; Yang, HR; Bai, LY

Bai, LY (corresponding author), China Med Univ Hosp, Dept Internal Med, Div Hematol & Oncol, 2 Yude Rd, Taichung 40402, Taiwan.

BIOCHEMICAL PHARMACOLOGY, 2020; 174 ():

Abstract

Pyruvate kinase M2 (PKM2) is a key enzyme responsible for the final step of glycolysis. It is still unclear whether PKM2 is involved in reactive oxyge......

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