CRISPR-mediated MECOM depletion retards tumor growth by reducing cancer stem cell properties in lung squamous cell carcinoma

Ma, YY; Kang, B; Li, SL; Xie, GY; Bi, JW; Li, FQ; An, G; Liu, B; Li, J; Shen, Y; Xu, X; Yang, HM; Yang, Y; Gu, Y; Wu, N

Yang, Y; Wu, N (通讯作者)，Peking Univ Canc Hosp & Inst, Dept Thorac Surg 2, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing, Beijing 100142, Peoples R China.;Gu, Y (通讯作者)，BGI Shenzhen, Guangdong Prov Key Lab Genome Read & Write, Shenzhen 518120, Peoples R China.

MOLECULAR THERAPY, 2022; 30 (11): 3341

Abstract

Targeted therapy for lung squamous cell carcinoma (LUSC) re-mains a challenge due to the lack of robust targets. Here, we identified MECOM as a candid......

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