APOE epsilon 4 genotype, amyloid-beta, and sex interact to predict tau in regions of high APOE mRNA expression

Dincer, A; Chen, CD; McKay, NS; Koenig, LN; McCullough, A; Flores, S; Keefe, SJ; Schultz, SA; Feldman, RL; Joseph-Mathurin, N; Hornbeck, RC; Cruchaga, C; Schindler, SE; Holtzman, DM; Morris, JC; Fagan, AM; Benzinger, TLS; Gordon, BA

Gordon, BA (通讯作者)，Washington Univ, Sch Med, Mallinckrodt Inst Radiol, St Louis, MO 63110 USA.;Gordon, BA (通讯作者)，Washington Univ, Knight Alzheimer Dis Res Ctr, Sch Med, St Louis, MO 63110 USA.;Gordon, BA (通讯作者)，Washington Univ, Sch Med, Hope Ctr Neurol Disorders, St Louis, MO 63110 USA.;Gordon, BA (通讯作者)，Washington Univ, Dept Psychol & Brain Sci, St Louis, MO 63110 USA.

SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (671):

Abstract

The apolipoprotein E (APOE) epsilon 4 allele is strongly linked with cerebral beta-amyloidosis, but its relationship with tauopathy is less establishe......

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