DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro

Bian, K; Lenz, SAP; Tang, Q; Chen, FY; Qi, R; Jost, M; Drennan, CL; Essigmann, JM; Wetmore, SD; Li, DY

Li, DY (reprint author), Univ Rhode Isl, Coll Pharm, Dept Biomed & Pharmaceut Sci, Kingston, RI 02881 USA.; Wetmore, SD (reprint author), Univ Lethbridge, Dept Chem & Biochem, 4401 Univ Dr West, Lethbridge, AB T1K 3M4, Canada.

NUCLEIC ACIDS RESEARCH, 2019; 47 (11): 5522

Abstract

5-Methylcytosine (5mC) in DNA CpG islands is an important epigenetic biomarker for mammalian gene regulation. It is oxidized to 5-hydroxymethylcytosin......

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