Zoobiquity experiments show the importance of the local MMP9-plasminogen axis in inflammatory bowel diseases in both dogs and patients

Yamasaki, T; Nagata, N; Atsumi, T; Hasebe, R; Tanaka, Y; Ohki, I; Kubota, S; Shinohara, Y; Bin Teoh, Y; Yokoyama, N; Sasaki, N; Nakamura, K; Ohta, H; Katsurada, T; Matsuno, Y; Hojyo, S; Hashimoto, S; Takiguchi, M; Murakami, M

Murakami, M (通讯作者),Hokkaido Univ, Inst Genet Med, Grad Sch Med, Div Mol Psychoimmunol, Sapporo, Japan.;Murakami, M (通讯作者),Natl Inst Nat Sci, Natl Inst Physiol Sci, Div Mol Neuroimmunol, Okazaki, Japan.;Takiguchi, M (通讯作者),Hokkaido Univ, Grad Sch Vet Med, Dept Clin Sci, Lab Vet Internal Med, Sapporo, Japan.;Murakami, M (通讯作者),Natl Inst Quantum & Radiol Sci & Technol QST, Inst Quantum Life Sci, Grp Quantum Immunol, Inage, Japan.;Murakami, M (通讯作者),Hokkaido Univ, Inst Vaccine Res & Dev HU IVReD, Sapporo, Japan.

INTERNATIONAL IMMUNOLOGY, 2023; 35 (7): 313

Abstract

Using a zoobiquity concept, we directly connect animal phenotypes to a human disease mechanism: the reduction of local plasminogen levels caused by ma......

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