Pilot Study of Delayed ICOS/ICOS-L Blockade With alpha CD40 to Modulate Pathogenic Alloimmunity in a Primate Cardiac Allograft Model

O'Neill, NA; Zhang, TS; Braileanu, G; Cheng, XF; Hershfeld, A; Sun, WJ; Reimann, KA; Dahi, S; Kubicki, N; Hassanein, W; Laird, C; Cimeno, A; Azimzadeh, AM; Pierson, RN

Pierson, RN (reprint author), Univ Maryland, Div Cardiac Surg, Dept Surg, Sch Med, 110 South Paca St,7N-134, Baltimore, MD 21201 USA.

TRANSPLANTATION DIRECT, 2018; 4 (2):

Abstract

Background. Inducible costimulator (ICOS) is rapidly upregulated with T-cell stimulation andmay represent an escape pathway for T-cell costimulation i......

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