Orail mediates tumor-promoting store-operated Ca2+ entry in human gastrointestinal stromal tumors via c-KIT and the extracellular signal-regulated kinase pathway

Wang, L; Hao, JQ; Zhang, YJ; Yang, ZY; Cao, Y; Lu, W; Shu, YJ; Jiang, L; Hu, YP; Lv, WJ; Liu, YB; Dong, P

Liu, YB; Dong, P (reprint author), Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp Affiliated, Dept Gen Surg, 1665 Kongjiang Rd, Shanghai, Peoples R China.

TUMOR BIOLOGY, 2017; 39 (2):

Abstract

Gastrointestinal stromal tumors originate from interstitial cells of Cajal, the pacemaker cells of the gut. Ca2+ regulates the pacemaker activity of i......

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