CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA

Mok, BY; Kotrys, AV; Raguram, A; Huang, TP; Mootha, VK; Liu, DR

Liu, DR (通讯作者)，Broad Inst MIT & Harvard, Merkin Inst Transformat Technol Healthcare, Cambridge, MA 02142 USA.;Liu, DR (通讯作者)，Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA.;Liu, DR (通讯作者)，Harvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA.

NATURE BIOTECHNOLOGY, 2022; 40 (9): 1378

Abstract

The all-protein cytosine base editor DdCBE uses TALE proteins and a double-stranded DNA-specific cytidine deaminase (DddA) to mediate targeted C cente......

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