Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers

DiPeri, TP; Evans, KW; Raso, MG; Zhao, M; Rizvi, YQ; Zheng, XF; Wang, BL; Kirby, BP; Kong, KT; Kahle, M; Yap, TA; Dumbrava, EE; Ajani, JA; Fu, SQ; Keyomarsi, K; Meric-Bernstam, F

Meric-Bernstam, F (通讯作者)，Univ Texas MD Anderson Canc Ctr, Dept Invest Canc Therapeut, 1400 Holcombe Blvd, Houston, TX 77030 USA.

CLINICAL CANCER RESEARCH, 2023; 29 (21): 4385

Abstract

Purpose: Cyclin E (CCNE1) has been proposed as a biomarker of sensitivity to adavosertib, a Wee1 kinase inhibitor, and a mechanism of resistance to HE......

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