Potent and Selective Mitogen-Activated Protein Kinase Kinase 1/2 (MEK1/2) Heterobifunctional Small-molecule Degraders

Hu, JP; Wei, JL; Yim, H; Wang, L; Xie, L; Jin, MS; Kabir, M; Qin, LH; Chen, X; Liu, J; Jin, J

JOURNAL OF MEDICINAL CHEMISTRY, 2020; 63 (24): 15883

Abstract

Previously, we reported a first-in-class von Hippel-Lindau (VHL)-recruiting mitogen-activated protein kinase kinases 1 and 2 (MEK1/2) degrader, MS432.......

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