Click strategy using disodium salts of amino acids improves the water solubility of plinabulin and KPU-300

Yakushiji, F; Muguruma, K; Hayashi, Y; Shirasaka, T; Kawamata, R; Tanaka, H; Yoshiwaka, Y; Taguchi, A; Takayama, K; Hayashi, Y

Hayashi, Y (reprint author), Tokyo Univ Pharm & Life Sci, Sch Pharm, 1432-1 Horinouchi, Hachioji, Tokyo 1920392, Japan.

BIOORGANIC & MEDICINAL CHEMISTRY, 2017; 25 (14): 3623

Abstract

Plinabulin and KPU-300 are promising anti-microtubule agents; however, the low water solubility of these compounds (<0.1 mu g/mL) has limited their......

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