Efficacy and Pharmacodynamic Modeling of the BTK Inhibitor Evobrutinib in Autoimmune Disease Models

Haselmayer, P; Camps, M; Liu-Bujalski, L; Nguyen, N; Morandi, F; Head, J; O'Mahony, A; Zimmerli, SC; Bruns, L; Bender, AT; Schroeder, P; Grenningloh, R

Grenningloh, R (reprint author), EMD Serono Res & Dev Inst Inc, 45A Middlesex Turnpike, Billerica, MA 01821 USA.

JOURNAL OF IMMUNOLOGY, 2019; 202 (10): 2888

Abstract

Because of its role in mediating both B cell and Fc receptor signaling, Bruton's tyrosine kinase (BTK) is a promising target for the treatment of auto......

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