CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies

Wang, DR; Prager, BC; Gimple, RC; Aguilar, B; Alizadeh, D; Tang, HZ; Lv, DG; Starr, R; Brito, A; Wu, QL; Kim, LJY; Qiu, ZX; Lin, P; Lorenzini, MH; Badie, B; Forman, SJ; Xie, Q; Brown, CE; Rich, JN

Xie, Q (corresponding author), Westlake Lab Life Sci & Biomed, 18 Shilongshan Rd, Hangzhou 310004, Zhejiang, Peoples R China.; Rich, JN (corresponding author), UPMC Hillman Canc Ctr, UPMC Canc Pavil,5150 Ctr Ave, Pittsburgh, PA 15232 USA.; Brown, CE (corresponding author), Cellular Immunotherapy Ctr, T Cell Therapeut Res Labs, 1500 E Duarte Rd, Duarte, CA 91007 USA.

CANCER DISCOVERY, 2021; 11 (5): 1192

Abstract

Glioblastoma (GBM) contains self-renewing GBM stem cells (GSC) potentially amenable to immunologic targeting, but chimeric antigen receptor (CAR) T-ce......

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