High-resolution mass spectrometry-based approach for the identification and profiling of the metabolites of taletrectinib formed in liver microsomes

Ye, YB; Guo, XJ; He, X; Zhang, MW; He, HQ; Qiu, DF; Guo, ZW

Guo, ZW (corresponding author), Sun Yat Sen Univ, Zhongshan Hosp, Dept Hematol, 2 East Sunwen Road, Zhongshan 528403, Peoples R China.; Guo, ZW (corresponding author), Zhongshan City Peoples Hosp, 2 East Sunwen Road, Zhongshan 528403, Peoples R China.

DRUG TESTING AND ANALYSIS, ; ():

Abstract

Taletrectinib is a potent, orally active, and selective ROS1/NTRK kinase inhibitor. The aim of this study was to study the metabolism of taletrectinib......

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