Cardioprotective effects of CYP-derived epoxy metabolites of docosahexaenoic acid involve limiting NLRP3 inflammasome activation

Darwesh, AM; Jamieson, KL; Wang, CY; Samokhvalov, V; Seubert, JM

Seubert, JM (reprint author), Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2R3, Canada.; Seubert, JM (reprint author), Univ Alberta, Fac Med & Dent, Dept Pharmacol, Edmonton, AB T6G 2R3, Canada.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2019; 97 (6): 544

Abstract

Impaired mitochondrial function and activation of NLRP3 inflammasome cascade has a significant role in the pathogenesis of myocardial ischemia-reperfu......

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