Osteoclasts Derive Predominantly from Bone Marrow-Resident CX(3)CR1(+) Precursor Cells in Homeostasis, whereas Circulating CX(3)CR1(+) Cells Contribute to Osteoclast Development during Fracture Repair

Novak, S; Roeder, E; Kalinowski, J; Jastrzebski, S; Aguila, HL; Lee, SK; Kalajzic, I; Lorenzo, JA

Lorenzo, JA (corresponding author), Univ Connecticut, Musculoskeletal Inst, UConn Hlth, N4054,Mail Code 4037,263 Farmington Ave, Farmington, CT 06030 USA.

JOURNAL OF IMMUNOLOGY, 2020; 204 (4): 868

Abstract

Osteoclasts (OC) originate from either bone marrow (BM)-resident or circulating myeloid OC progenitors (OCP) expressing the receptor CX(3)CR1. Multipl......

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