Structure-based design, synthesis, and evaluation of inhibitors with high selectivity for PARP-1 over PARP-2

Yu, J; Luo, LL; Hu, T; Cui, YT; Sun, X; Gou, WF; Hou, WB; Li, YL; Sun, TM

Sun, TM (通讯作者)，Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China.;Li, YL (通讯作者)，Peking Union Med Coll & Chinese Acad Med Sci, Inst Radiat Med, Tianjin Key Lab Radiat Med & Mol Nucl Med, Tianjin 300192, Peoples R China.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022; 227 ():

Abstract

The poly (ADP-ribose) polymerase (PARP) inhibitors play a crucial role in cancer therapy. However, most approved PARP inhibitors have lower selectivit......

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