Fit-for-purpose synthesis of dual leucine zipper kinase (DLK) inhibitor GNE-834

Xu, J; Carrera, DE; Beaudry, D; Siu, M; Huestis, MP; Liu, W; Angelaud, R; Gosselin, F

Xu, J (corresponding author), Genentech Inc, Dept Small Mol Proc Chem, 1 DNA Way, San Francisco, CA 94080 USA.

TETRAHEDRON LETTERS, 2020; 61 (43):

Abstract

A practical fit-for-purpose synthesis of dual leucine zipper kinase (DLK) inhibitor GNE-834 (1) was developed. The key C-C bond was constructed via a ......

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